Santiago is the largest city in Chile, and it’s the political, financial, and cultural center of the country. The city is home to more than 6 million people and is located in the middle of the Santiago Basin surrounded by the Andes Mountains. It was initially founded in 1541, and there are areas of the city that reflect over 450 years of history in its architecture and cobblestone streets. There is so much to do in one of the oldest cities in the Western Hemisphere. Plaza de Armas, the heart of the city’s old colonial core, is home to 2 famous landmarks: the 1808 Palacio de la Real Audiencia, housing the National History Museum, and the 18th-century Metropolitan Cathedral.